Toys that inactivate dog dental disease pathogens.
A patented technology.

Chulites emit ‘Soret band’ light, a harmless visible violet wavelength absorbed by disease-causing bacteria. These bacteria exchange energy with oxygen, which oxidizes their own membranes.

Chulites pack this safe, powerful light in orbs and wands, that go into chew toys. Dogs grip it in their mouths, the light turns on, and in a few minutes pathogen loads get reduced by an order of magnitude.

Trial Runs

A CONTROLLED TRIAL
Chulites plans a controlled trial. The evidence for Chulite effectiveness is well established scientifically, has a sound theoretical basis, with robust laboratory and hospital results. What remains is product testing.

There are at least eight scientific research studies that demonstrate exactly what Chulites can do. There are many more that show why they should work. The devices are designed to fit the different jaw strength and mouth sizes in dogs, using carefully gathered data. Controlled trials are necessary.

Check Out the Chulite Trial Description.

HOW THEY WORK


Chulites prevent dog periodontal disease.



WHY THEY WORK





Bacteria all the way down.
Gram-negative periodontal pathogens contain porphyrins that absorb Soret-band light, which expands the electron cloud around their pyrrole rings, inducing energy transfer to passing oxygen, leading to a peroxidation cascade.


In-vitro and in-vivo studies provide key data. They identify the dose of light that inactivates one or more orders of magnitude of Gram-negative bacteria.

Consumers may compare Chulites to abrasive chew toys, whose “nibs” and “spines” loosen oral material. Such toys may reduce plaque. Chulites inactivate bacteria. That’s what antibiotics do.



Blinded Trial



Antibiotics, those things that save millions of lives … When new antibiotics are tested, they don’t have to be better than existing ones. If they’re just as good, they’re good enough. An antibiotic becomes less effective over time, predictably, because of bacterial resistance. If the new one is as good as the old one was, it’s a keeper. It should still be effective after the old one fades, due to bacterial resistance.
Chulites use light. That light was tested on many bacteria generations in attempts to induce resistance. They didn’t. It’s not surprising. Antibiotics are culled from fungi and bacteria that are long-term (hundreds of millions of years) evolutionary competitors of pathogens. The bacteria populations under attack already have adaptive genes. Their transfer to surviving bacteria is inevitable. But a light wavelength is not an evolutionary competitor, so bacteria have no latent genetic capacity to exploit.
Speaking of resistance, antibiotics shouldn’t be used for prophylactic purposes, like preventing disease. Crest and Colgate act in the public interest, by not putting antibiotics in their products. Given that Colgate’s dental paste is the world’s most widespread branded product, an antibiotic ingredient would be rapidly undermined by resistance.





That leads to …
A trial in which Chulites will be compared to no treatment. Instead of dog testers being “blind” to which dogs get treated, dogs are assigned randomly to conditions, their identity is removed from samples, and lab workers and statistical analysts don’t know them. Mouths of both treated and untreated dogs will be sampled, anonymized, and sent to a lab. The lab won’t know which are from treated or untreated dogs. Gram-negative bacteria loads will be measured, and results analyzed without treatments identified.